NFL Week 3 betting: Odds, lines and totals for every game

Bills projected heavy favorites in Week 3 — Bills -13.5 vs. Dolphins suggests bettors may back Buffalo on the spread or moneyline; consider the 49.5 total for Over/Under action as both offenses look for bounce-back performances.

Week 3 NFL Odds and Key Matchups

Week 3 opens with an AFC East clash as Buffalo hosts Miami, and the slate includes several high-profile matchups between unbeaten teams and early-season slip-ups. Betting lines show clear favorites in multiple games, while others remain toss-ups — useful context for spreads, moneylines and totals ahead of wagering.

Miami Dolphins at Buffalo Bills — Bills big favorites

Buffalo enters as a heavy favorite after a dominant start, listed at -13.5. The total sits near 49.5. The Bills’ strong early form suggests confidence for bettors on Buffalo covering the spread or taking the moneyline, while totals bettors should weigh both teams’ offensive outputs and turnovers.

Los Angeles Rams at Philadelphia Eagles — undefeated showdown

The Eagles are slight favorites at -3.5 in a matchup of 2-0 teams. Total is 44.5. Expect a competitive game that could hinge on defensive stops and red‑zone efficiency — factors that matter for spread and prop bets.

Arizona Cardinals at San Francisco 49ers — close divisional test

Line is tight with San Francisco favored by about 1.5 and a 44.5 total. The small spread points to a betting market that sees this as a coin-flip; look at matchups and weather if placing a play.

Kansas City Chiefs at New York Giants — Chiefs favored

Chiefs projected around -6.5 with a 44.5 total. Kansas City’s offensive ceiling makes them attractive on the spread and moneyline, but the Giants’ home advantage and recent form deserve consideration for contrarian bettors.

Detroit Lions at Baltimore Ravens — Monday night spotlight

Ravens about -5.5 with a 51.5 total in a late-week marquee game. High total suggests potential for yardage-heavy performances; props on passing yards and scoring drives could be productive.

Full Week 3 Odds (Spread | Moneyline | Total | Projected win probability)

Miami Dolphins vs. Buffalo Bills — Spread: Bills -13.5 | Moneyline: Dolphins +550, Bills -900 | Total: 49.5 | FPI: Bills ~75.9% New York Jets vs. Tampa Bay Buccaneers — Spread: Buccaneers -6.5 | Moneyline: Jets +260, Buccaneers -320 | Total: 44.5 | FPI: Buccaneers ~67.5% Indianapolis Colts vs. Tennessee Titans — Spread: Colts -3.5 | Moneyline: Colts -185, Titans +155 | Total: 43.5 | FPI: Colts ~67.5% Las Vegas Raiders vs. Washington Commanders — Spread: Commanders -5.5 | Moneyline: Raiders +220, Commanders -270 | Total: 46.5 | FPI: Commanders ~62.7% Los Angeles Rams vs. Philadelphia Eagles — Spread: Eagles -3.5 | Moneyline: Rams +160, Eagles -190 | Total: 44.5 | FPI: Eagles ~57.6% Atlanta Falcons vs. Carolina Panthers — Spread: Falcons -3.5 | Moneyline: Falcons -215, Panthers +180 | Total: 43.5 | FPI: Falcons ~57.1% Houston Texans vs. Jacksonville Jaguars — Spread: Jaguars -1.5 | Moneyline: Texans +100, Jaguars -120 | Total: 44.5 | FPI: Jaguars ~52.1% Green Bay Packers vs. Cleveland Browns — Spread: Packers -8.5 | Moneyline: Packers -450, Browns +340 | Total: 42.5 | FPI: Packers ~70.5% Pittsburgh Steelers vs. New England Patriots — Spread: Steelers -1.5 | Moneyline: Steelers -120, Patriots +100 | Total: 44.5 | FPI: Patriots ~50.3% Cincinnati Bengals vs. Minnesota Vikings — Spread: Vikings -3.5 | Moneyline: Bengals +150, Vikings -175 | Total: 41.5 | FPI: Vikings ~51.3% Denver Broncos vs. Los Angeles Chargers — Spread: Chargers -2.5 | Moneyline: Broncos +125, Chargers -145 | Total: 45.5 | FPI: Chargers ~56.5% New Orleans Saints vs. Seattle Seahawks — Spread: Seahawks -7.5 | Moneyline: Saints +300, Seahawks -400 | Total: 41.5 | FPI: Seahawks ~64.2% Arizona Cardinals vs. San Francisco 49ers — Spread: 49ers -1.5 | Moneyline: Cardinals +100, 49ers -120 | Total: 44.5 | FPI: Cardinals ~52.3% Dallas Cowboys vs. Chicago Bears — Spread: Cowboys -1.5 | Moneyline: Cowboys +105, Bears -125 | Total: 49.5 | FPI: Cowboys ~53.1% Kansas City Chiefs vs. New York Giants — Spread: Chiefs -6.5 | Moneyline: Chiefs -275, Giants +225 | Total: 44.5 | FPI: Chiefs ~66.7% Detroit Lions vs. Baltimore Ravens — Spread: Ravens -5.5 | Moneyline: Lions +210, Ravens -250 | Total: 51.5 | FPI: Ravens ~56.1%

How bettors can approach Week 3

Focus on matchups with clear favorites for spread and moneyline plays, but shop lines where possible. For close spreads (1–4 points), evaluate situational factors — injuries, turnovers, and home-field edge. Totals near league averages suggest leaning on team trends and weather/venue. Late-week market moves could open value as information emerges.

If you want, I can tailor recommended plays (spread, moneyline or totals) based on your bankroll, risk tolerance and preferred teams.

Odds, spreads, totals and FPI predictions for all 16 NFL games in Week 3.

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