Is Kyler Murray playing today? Latest injury update on Cardinals QB for Week 6

Kyler Murray is expected to miss Week 6 with a mid-foot (Lisfranc-type) sprain, giving Jacoby Brissett the start. Betting impact: back the Colts or consider Arizona’s team total under and Brissett passing props — expect a downgraded Cardinals offense without Murray and two injured RBs.

Cardinals QB update: Murray not expected to play Week 6

Kyler Murray was added to the injury report after exiting Week 5 with a foot injury and did not practice early in the week before a limited Friday session. Late updates indicate Murray is not expected to play in Week 6 as he deals with a mid-foot sprain that’s being treated as a Lisfranc-type injury.

Injury specifics and outlook

The mid-foot sprain carries risk of aggravation if rushed, and there is a possibility Murray could miss more than one game. The team will monitor him, but medical caution suggests limited short-term availability.

Who starts for Arizona: Brissett in, Slovis elevated

Jacoby Brissett will take over under center. Brissett has limited action this season and a 19-34 record as a career starter. Kedon Slovis was promoted from the practice squad to serve as Brissett’s backup.

Depth-chart and offensive consequences

Arizona also faces injuries at running back — key contributors are sidelined — which compounds the loss of Murray. The offense is likely to be less explosive and more conservative with Brissett at the helm.

Matchup implications and betting angles

Facing one of the league’s top offenses through five weeks, the Cardinals are a less reliable betting option without Murray. Practical betting moves: - Back the Colts moneyline or consider taking them against the spread if Murray is officially out. - Consider Arizona’s team total under and lower passing-yard props for Brissett. - Monitor injury reports and market movement up to kickoff for sharper lines and player-prop adjustments.

Arizona Cardinals quarterback Kyler Murray has drawn a questionable tag for the Week 6 game against the Indianapolis Colts. Here's the latest update on Murray's status for Sunday.

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